Forward genetic screen of human transposase genomic rearrangements.

Anton G HenssenEileen JiangJiali ZhuangLuca PinelloNicholas D SocciRichard KocheMithat GonenCamila M VillasanteScott A ArmstrongDaniel E BauerZhiping WengAlex Kentsis

Published in: BMC genomics (2016)

The discovered PSS motifs and high-throughput forward chemical genomic screening approach should prove useful for the elucidation of endogenous genome remodeling activities of PGBD5 and other domesticated human DNA transposases and recombinases.

Keyphrases

high throughput
endothelial cells
copy number
induced pluripotent stem cells
genome wide
dna methylation
single molecule