High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.

Kursat GundoganMary M NellisNurhayat T OzerSerap S ErgulGulsah G SahinSahin TemelRecep C YukselSami TeenyJessica A AlvarezMurat SungurDean P JonesThomas R Ziegler

Published in: Metabolomics : Official journal of the Metabolomic Society (2024)

Plasma HRM revealed that thiamine status, determined by whole blood TPP concentrations, was significantly associated with metabolites and metabolic pathways related to metabolism of energy, carbohydrates, amino acids, lipids, and the gut microbiome in adult critically ill patients.

Keyphrases

high resolution
amino acid
mass spectrometry
ms ms
single cell
fatty acid
young adults
liquid chromatography
drug induced