Endothelial prostaglandin D2 opposes angiotensin II contractions in mouse isolated perfused intracerebral microarterioles.

L LiE Y LaiX CaoW J WelchChristopher S Wilcox

Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2021)

The resilience of cerebral arterioles to Ang II contractions is specific for intraparenchymal microarterioles and depends on endothelial COX1 and two products that are metabolized by L-PGDS to generate PGD2 that signals via DP1Rs and NO.

Keyphrases

angiotensin ii
angiotensin converting enzyme
vascular smooth muscle cells
endothelial cells
climate change
social support
blood brain barrier
cerebral ischemia
depressive symptoms
cerebral blood flow