Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in TP53-Mutant Cancers.

Jeffrey Patterson-Fortin Arindam Bose Wei-Chih Tsai Carter Grochala Huy Nguyen Jia Zhou Kalindi Parmar Jean-Bernard Lazaro Joyce F Liu Kelsey McQueen Geoffrey I Shapiro David E Kozono Alan D' Andrea

Published in: Cancer research (2022)

Combined inhibition of NHEJ and MMEJ using two nontoxic, targeted DNA repair inhibitors can effectively induce toxic DNA damage to treat TP53-deficient cancers.

Keyphrases

dna repair
dna damage
dna damage response
cancer therapy
oxidative stress
wild type