Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC).
Shi-Yi LiuSaijiao LiYanqing WangFeiyan WangLi ZhangShu XianDongyong YangMengqin YuanFangfang DaiXin ZhaoYuping LiuYumeng JinZihang ZengOmer Kamal Ahmed MahgoubChenliang ZhouYanxiang ChengPublished in: Journal of cellular biochemistry (2019)
In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the "Estimation of STromal and Immune cells in MAlignant Tumours using Expression data" algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC.
Keyphrases
- cell proliferation
- poor prognosis
- pi k akt
- immune response
- induced apoptosis
- cell cycle arrest
- bone marrow
- genome wide
- squamous cell carcinoma
- machine learning
- gene expression
- endothelial cells
- oxidative stress
- signaling pathway
- electronic health record
- dendritic cells
- cell death
- artificial intelligence
- binding protein
- mass spectrometry
- single molecule