Low dose Intralipid resuscitation improves survival compared to ClinOleic in propranolol overdose in rats.

Kimberly F MacalaRachel G KhadarooSareh PanahiFerrante S GragasinStephane L Bourque

Published in: PloS one (2018)

Low-dose Intralipid (1, 2, or 3 mL/kg IV) confers a survival advantage up to 120 minutes post-propranolol overdose (the end-point of the experiment) and better hemodynamic recovery compared to ClinOleic (1, 2, or 3 mL/kg IV) in rats with propranolol overdose. As health care centres choose alternate intravenous lipid emulsions, limited availability of Intralipid could impact efficacy and success of overdose treatment for lipid-soluble drugs.

Keyphrases

low dose
high dose
healthcare
cardiac arrest
fatty acid
combination therapy
septic shock
smoking cessation