Cross-sectionally calculated metabolic ageing does not relate to longitudinal metabolic changes - support for stratified ageing models.
Mika Ala-KorpelaTerho LehtimäkiMika KÄhÖnenJorma ViikariMarkus PerolaVeikko V SalomaaJohannes KettunenOlli T RaitakariVille-Petteri MakinenPublished in: The Journal of clinical endocrinology and metabolism (2023)
The finding is unexpected under the clock hypothesis that would produce a positive correlation between predicted and observed ageing. Our results are better explained by a stratified model where ageing rates per se are similar in adulthood but differences in starting points explain diverging metabolic fates.
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