Development of cobalt (Co)-doped monetites for bone regeneration.
Gerson Santos de AlmeidaMarcel Rodrigues FerreiraCélio Junior da Costa FernandesLuísa Camilo SuterMaria Gabriela Jacheto CarraDiego Rafael Nespeque CorreaElidiane Cipriano RangelMargarida Juri SaekiWillian Fernando ZambuzziPublished in: Journal of biomedical materials research. Part B, Applied biomaterials (2023)
Cobalt-doped monetite powders were synthesized by coprecipitation method under a cobalt nominal content between 2 and 20 mol % of total cation. Structural characterization of samples was performed by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. XRD results indicated that the Co-doped samples exhibited a monetite single-phase with the cell parameters and crystallite size dependent on the amount of substitutional element incorporated into the triclinic crystalline structure. Cell viability and adhesion assays using pre-osteoblastic cells showed there is no toxicity and the RTqPCR analysis showed significant differences in the expression for osteoblastic phenotype genes, showing a potential material for the bone regeneration.
Keyphrases
- electron microscopy
- bone regeneration
- metal organic framework
- quantum dots
- highly efficient
- reduced graphene oxide
- ionic liquid
- induced apoptosis
- high resolution
- poor prognosis
- vascular smooth muscle cells
- visible light
- carbon nanotubes
- single cell
- cell cycle arrest
- cell therapy
- oxidative stress
- genome wide
- dna methylation
- binding protein
- cell death
- magnetic resonance imaging
- mass spectrometry
- computed tomography
- long non coding rna
- gas chromatography
- pi k akt
- cell proliferation
- genome wide identification
- cell adhesion
- contrast enhanced