The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract.
Monika PinkasTomasz BrzozowskiPublished in: Antioxidants (Basel, Switzerland) (2024)
Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of exercise on health. Irisin may be a potential therapeutic agent against obesity and has been shown to play an important role in the protection of various cells, tissues, and organs due to its anti-inflammatory, antioxidative, and anti-cancer properties. Our aim was to review the recent experimental and clinical studies on irisin and its expression, release into the bloodstream, tissue targets, and potential contribution to the protective effects of exercise in the gastrointestinal tract. Particular emphasis was placed on inflammatory bowel disease, intestinal ischemia/reperfusion injury, periodontitis, and other digestive tract disorders, including carcinogenesis. Overall, irisin holds significant potential as a novel target molecule, offering a safe and therapeutic approach to treating various gastrointestinal diseases.
Keyphrases
- adipose tissue
- anti inflammatory
- ischemia reperfusion injury
- insulin resistance
- human health
- healthcare
- high intensity
- poor prognosis
- induced apoptosis
- public health
- gene expression
- physical activity
- type diabetes
- metabolic syndrome
- mental health
- cell cycle arrest
- high fat diet
- risk assessment
- resistance training
- cell death
- escherichia coli
- body mass index
- skeletal muscle
- binding protein
- long non coding rna
- multidrug resistant
- health promotion