Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data.
Zhi ZhouIkuko YanoSumiko OdakaYosuke MoritaSatoshi ShizutaMamoru HayanoTakeshi KimuraAkinori AkaikeKen-Ichi InuiKazuo MatsubaraPublished in: Journal of pharmaceutical health care and sciences (2016)
A pharmacokinetic/pharmacodynamic model was successfully built to explain the retrospective INR data during catheter ablation. Simulation studies suggest that vitamin K2 should be administered with care and that more than 20 mg is unnecessary in the preoperative period of catheter ablation.
Keyphrases
- catheter ablation
- atrial fibrillation
- left atrial
- left atrial appendage
- direct oral anticoagulants
- oral anticoagulants
- electronic health record
- patients undergoing
- cross sectional
- heart failure
- healthcare
- big data
- venous thromboembolism
- palliative care
- cardiac surgery
- quality improvement
- data analysis
- pain management
- machine learning
- deep learning