The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia.
Patrick WilliamsSreyashi BasuGuillermo Garcia-ManeroChristopher S HouriganKarolyn A OetjenJorge E CortesFarhad RavandiElias J JabbourZainab Al-HamalMarina KonoplevaJing NingLianchun XiaoJuliana Hidalgo LopezSteve M KornblauMichael AndreeffWilmer FloresCarlos Bueso-RamosJorge BlandoPallavi GaleraKatherine R CalvoGheath Al-AtrashJames P AllisonHagop M KantarjianPadmanee SharmaNaval G DaverPublished in: Cancer (2018)
The preserved T-cell population, the increased frequency of regulatory T cells, and the expression of targetable immune receptors in AML BMAs suggest a role for T-cell-harnessing therapies in AML.