CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues.

Jonathan M BrungerAnanya ZutshiVincent P WillardCharles A GersbachFarshid Guilak

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2017)

This work demonstrates proof-of-concept of the ability to engineer custom-designed stem cells that are immune to proinflammatory cytokines (i.e., IL-1) as a potential cell source for cartilage tissue engineering.

Keyphrases

crispr cas
tissue engineering
induced pluripotent stem cells
stem cells
genome editing
cell therapy
oxidative stress
single cell
gene expression
extracellular matrix
human health
risk assessment
bone marrow