Expression of the alternative splicing regulator Rbfox2 during placental development is differentially regulated in preeclampsia mouse models.

Nancy FreitagYiran XieLisa-Marie AdamSophia BorowskiSandra M Blois Gabriela Barrientos

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)

Our findings uncover a novel role for Rbfox2-controlled splicing events in the modulation of trophoblast function, with potential implications for the pathogenesis of preeclampsia and other pregnancy complications originated from defective placentation.

Keyphrases

pregnancy outcomes
early onset
transcription factor
mouse model
poor prognosis
pregnant women
preterm birth
risk factors
human health
risk assessment