Non-coding variants impact cis-regulatory coordination in a cell type-specific manner.

Olga PushkarevGuido van MierloJudith Franziska KribelbauerWouter SaelensVincent GardeuxBart Deplancke

Published in: Genome biology (2024)

Our study presents an optimal strategy for CM mapping and reveals how CMs capture the coordination of CREs and its impact on gene expression. Non-coding genetic variants can disrupt this coordination, and we highlight how this may lead to disease predisposition in a cell type-specific manner.

Keyphrases

gene expression
dna methylation
high resolution
copy number
transcription factor
genome wide