Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019.

James ReganJames P FlynnAlexandra RosenthalHannah JordanYijia LiRida ChishtiFrancoise GiguelHeather CorryKendyll CoxenJesse FajnzylberElizabeth GillespieDaniel R KuritzkesNir HacohenMarcia B GoldbergMichael R FilbinXu G YuLindsey BadenRuy M RibeiroAlan S PerelsonJessica M ConwayJonathan Z Linull null

Published in: Open forum infectious diseases (2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.

Keyphrases

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sars cov
coronavirus disease
cystic fibrosis
pulmonary tuberculosis
randomized controlled trial
combination therapy
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sleep quality
replacement therapy
smoking cessation
study protocol