Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts.

Greta K WoodRoshan BabarMark A EllulRhys Huw Thomas Harriet Van Den ToorenAva EastonKukatharmini TharmaratnamGirvan BurnsideAli M AlamHannah CastellSarah BoardmanCeryce CollieBethany FacerCordelia DunaiSylviane DefresJulia GranerodDavid W G BrownAngela VincentAnthony Guy MarsonSarosh R IraniTom SolomonBenedict D Michael

Published in: BMJ neurology open (2022)

Age, GCS, fever and aetiology can effectively stratify acute seizure risk in patients with encephalitis. These findings can support the development of targeted interventions and aid clinical trial design for antiseizure medication prophylaxis.

Keyphrases

clinical trial
liver failure
respiratory failure
drug induced
study protocol
aortic dissection
healthcare
double blind
cancer therapy
emergency department
cross sectional
temporal lobe epilepsy
phase ii
extracorporeal membrane oxygenation
acute respiratory distress syndrome
electronic health record
phase iii