NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer.

Daniela MarzioniRoberta MazzucchelliSonia FantoneGiovanni Tossetta

Published in: Molecular biology reports (2022)

We can conclude that specific natural and synthetic compounds can downregulate DNMTs and/or HDACs inhibiting the methylation status of NRF2 promoter, then reactivating the expression of NRF2 protecting normal prostatic cells from ROS damage and tumorigenesis.

Keyphrases

oxidative stress
prostate cancer
radical prostatectomy
dna methylation
poor prognosis
dna damage
gene expression
cell death
transcription factor
high fat diet induced
insulin resistance
skeletal muscle
binding protein
benign prostatic hyperplasia