Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population.
Marco A Rocha LouresLuciana C MacedoDenise M ReisCamila F OliveiraJean L MeneguettiGabriela F MartinesJanisleya S F NevesEliana de SouzaAna Maria SellJeane Eliete Laguila VisentainerPublished in: Mediators of inflammation (2018)
In this Brazilian population, TNF and IL17 gene polymorphisms responsible for the expression of important inflammatory cytokines were associated with overall SpA, and, specifically, with AS and PsA, regardless of gender and HLA-B27. However, future larger studies with different ethnicities may be necessary to confirm these genetic associations.