Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study.
Jing WangSteven W H ChauSiu Ping LamYaping LiuJihui ZhangNgan Yin ChanMaxine M S CheungMandy Wai Man YuJessie C T TsangJoey W Y ChanBei HuangShirley X LiVincent MokYun-Kwok WingPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
Almost 9% of patients with MDD in the psychiatric outpatient clinic has vPSG-confirmed RBD. Comorbid MDD+RBD may represent a subtype of MDD with underlying α-synucleinopathy neurodegeneration. Systematic screening of RBD symptoms and necessity of vPSG confirmation should be highlighted for capturing this MDD subtype with a view to enhance personalised treatment and future neuroprotection to prevent neurodegeneration.