Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors.
Ghada M A AjabnoorSuhad M BahijriNoor Ahmad ShaikAnwar BoraiAliaa A AlamoudiJumana Y Al-AamaGeorge P ChrousosPublished in: PloS one (2017)
Ramadan fasting in Saudi Arabia is associated with improvements in some cardiometabolic risk factors, such as circulating GGT and hsCRP and leukocyte expression of IL-1α mRNA, suggesting that intermittent fasting might have a beneficial component. These benefits may be offset by the previously reported dysregulation in the circadian rhythm, excess glucocorticoid levels and action, and insulin resistance, explaining increased prevalence of cardiometabolic disorders and type 2 diabetes mellitus.
Keyphrases
- risk factors
- insulin resistance
- poor prognosis
- blood glucose
- adipose tissue
- binding protein
- metabolic syndrome
- high fat diet
- skeletal muscle
- glycemic control
- type diabetes
- polycystic ovary syndrome
- blood pressure
- high fat diet induced
- genome wide
- long non coding rna
- atrial fibrillation
- gene expression
- high intensity
- cardiovascular disease
- peripheral blood
- cardiovascular risk factors
- genome wide analysis