Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery.

Zhiliang GaoXiaoyu LiKaijie ZhaoHuimin GengPeiyu Zhang Yi JuPie HudaChristopher B Howard Kristofer J Thurecht Muthupandian Ashokkumar Jingcheng Hao Jiwei Cui

Published in: Chemical communications (Cambridge, England) (2022)

Confined sono-polymerization is developed to prepare poly(ethylene glycol) nanoparticles within water-in-oil microemulsion, followed by post-functionalization with a bispecific antibody (anti HER2 and anti PEG) for targeted delivery of photosensitizers ( i.e. , indocyanine green). The nanoparticles could specifically target to breast cancer cells ( i.e. , SKBR3) that overexpress HER2 receptors for the inhibition of cancer cell growth under 808 nm laser irradiation. This study highlights a facile and controllable method to fabricate therapeutic nanoparticles capable of targeted delivery.

Keyphrases

breast cancer cells
photodynamic therapy
drug delivery
walled carbon nanotubes
radiation therapy
young adults
fatty acid
quantum dots
reduced graphene oxide
radiation induced
childhood cancer