AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation.

Rongquan SunZhifei LinXiangyu WangLu LiuMeisi HuoRui ZhangJing LinChao XiaoYitong LiWenwei ZhuLu LuJubo ZhangJin-Hong Chen

Published in: Journal of experimental & clinical cancer research : CR (2022)

AADAC protects metastatic CRC cells from ferroptosis by inhibiting lipid peroxidation in an SLC7A11-dependent manner, thus effectively promoting their metastatic colonization and growth in the liver. Together, our findings suggest that AADAC can act as a prognostic indicator and potential therapeutic target for CRLM.

Keyphrases

cell death
squamous cell carcinoma
small cell lung cancer
fatty acid
signaling pathway
risk assessment