Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model.

Hyeryon Lee Arim Yeom Kwan Chang Kim Young Mi Hong

Published in: Korean circulation journal (2019)

Ambrisentan administration resulted in the recovery of ET-1, ERA and eNOS protein expression levels in the PAH model. However, the expression level of NOX4 remained unaffected after ambrisentan treatment.

Keyphrases

pulmonary arterial hypertension
nitric oxide synthase
pulmonary hypertension
poor prognosis
pulmonary artery
nitric oxide
binding protein
endothelial cells
high glucose
stem cells
diabetic rats
long non coding rna
mesenchymal stem cells
coronary artery
signaling pathway
combination therapy
replacement therapy