TGFβ and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas.
Michael NipperYi XuJun LiuXue YinZhijie LiuZhengqing YeJianmin ZhangYidong ChenPei WangPublished in: Cells (2024)
Our study reveals the intricate transition between acinar and AD states in human pancreatic tissues. It unveils the complex interaction between the Hippo and TGF-β pathways during ADM, highlighting the pivotal role of YAP1/TAZ and SMAD4 in PDAC initiation.