Therapeutic Effects of Arctiin on Alzheimer's Disease-like Model in Rats by Reducing Oxidative Stress, Inflammasomes and Fibrosis.
Mohamed T AlmeaqliYazeed AlaidaaFaisal M AlnajjarAbdullah S Al ShararhDanah S AlharbiYazeed I AlmslmaniYousef A AlotibiHani S AlrashidiWael A ShehriHanan M HassanMohammed M H Al-GayyarPublished in: Current Alzheimer research (2024)
Arctiin can enhance rats' behavior and structure of the hippocampus in AD rats. This is achieved through its ability to reduce the expression of both TLR4 and NLRP3, hence inhibiting the inflammasome pathway. Furthermore, Arctiin can improve tissue fibrosis by regulating STAT3 and TGF-β. Lastly, it can block the cell cycle proteins cyclin D1 and CDK2.