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Proteoglycans in breast cancer, identification and characterization by LC-MS/MS assisted proteomics approach: A review.

Ajeeshkumar Kizhakkeppurath KumaranAnkita SahuAstha SinghNisha Aynikkattil RavindranNiladri Sekhar ChatterjeeSuseela MathewSaurabh Verma
Published in: Proteomics. Clinical applications (2023)
Proteomics techniques including LC-MS/MS-based identification of proteoglycans is effectively carried out in breast cancer research. Identification of expression at different stages of breast cancer is a major challenge, and LC-MS/MS-based profiling of PGs can boost novel strategies to treat breast cancer, which involve targeting PGs, and also aid early diagnosis using PGs as biomarkers.
Keyphrases
  • mass spectrometry
  • poor prognosis
  • long non coding rna
  • cancer therapy
  • bioinformatics analysis