Ultrahigh Resolution Mass Spectrometry Imaging Maps Brain Lipidome Alterations Associated with Mild Traumatic Brain Injury.

The lipid alterations observed indicate that neuroinflammation, oxidative stress and disrupted sodium-potassium pumps are important pathologies that can explain cognitive deficits associated with mTBI. Therapeutics which target and attenuate these pathologies may be beneficial to limit persistent damage following a mild brain injury.