Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis.
Jinming WenPang LyuIris StolzerJin XuAndreas GießlZhen LinDarja AndreevKaterina KachlerRui SongXianyi MengShan CaoGiuliana GugginoFrancesco CicciaClaudia GüntherLarissa Valor-MéndezAline BozecPublished in: Annals of the rheumatic diseases (2022)
These findings show that the HIF2α-CLDN15 axis is critical for the breakdown of intestinal barrier function at onset of arthritis, highlighting the functional link between intestinal homeostasis and arthritis.