Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells.

Xiaohui ZhouJing LiuSiyi YangYanguang SuZhipeng Meng Yuqin Hu

Published in: Clinics (Sao Paulo, Brazil) (2020)

Ketamine reduces hypoxia-induced p66Shc expression and attenuates ROS accumulation via upregulating sirt1 in HUVECs, thus attenuating hypoxia-induced endothelial cell inflammation and apoptosis.

Keyphrases

endothelial cells
oxidative stress
dna damage
pain management
cell death
high glucose
poor prognosis
ischemia reperfusion injury
vascular endothelial growth factor
cell cycle arrest
endoplasmic reticulum stress
reactive oxygen species
mouse model
binding protein
long non coding rna
chronic pain