Modification of the Antibiotic, Colistin, with Dextrin Causes Enhanced Cytotoxicity and Triggers Apoptosis in Myeloid Leukemia.
Siân RizzoMathieu VaracheEdward John SayersArwyn T JonesAlex TonksDavid W ThomasElaine L FergusonPublished in: International journal of nanomedicine (2024)
Whilst clinical translation of dextrin-colistin conjugates for the treatment of AML is unlikely due to the potential to promote antimicrobial resistance (AMR) and the relatively high colistin concentrations required for anticancer activity, the ability to potentiate the effectiveness of an anticancer drug by polymer conjugation, while reducing side effects and improving biodistribution of the drug, is very attractive, and this approach warrants further investigation.
Keyphrases
- antimicrobial resistance
- acinetobacter baumannii
- escherichia coli
- klebsiella pneumoniae
- pseudomonas aeruginosa
- acute myeloid leukemia
- gram negative
- multidrug resistant
- drug resistant
- bone marrow
- randomized controlled trial
- systematic review
- oxidative stress
- endoplasmic reticulum stress
- cystic fibrosis
- adverse drug
- dendritic cells
- cell death
- drug induced
- emergency department
- allogeneic hematopoietic stem cell transplantation
- cancer therapy
- risk assessment
- immune response
- human health