Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI.

Maxwell T LawsRobin E BonomiDavid J GelovaniJeremy LlaniguezXin LuThomas MangnerJuri George Gelovani

Published in: Neuro-oncology advances (2020)

PET/CT/MRI with 2-[18F]BzAHA can facilitate studies to elucidate the roles of SIRT1 in gliomagenesis and progression, as well as to optimize therapeutic doses of novel SIRT1 inhibitors.

Keyphrases

pet ct
contrast enhanced
oxidative stress
ischemia reperfusion injury
magnetic resonance imaging
positron emission tomography
poor prognosis
diffusion weighted imaging
computed tomography