Developmental Pathways Are Epigenetically Reprogrammed during Lung Cancer Brain Metastasis.

Jennifer A KarlowSiddhartha DevarakondaXiaoyun XingHyo Sik JangRamaswamy GovindanMark A Watson Ting Wang

Published in: Cancer research (2022)

Altered DNA methylation in lung cancer brain metastases corresponds with loss of EZH2 occupancy at developmental genes, which could promote stem-like phenotypes permissive of dissemination and survival in different microenvironments.

Keyphrases

brain metastases
dna methylation
small cell lung cancer
genome wide
long noncoding rna
gene expression
white matter
long non coding rna
resting state
free survival
genome wide identification
bioinformatics analysis
copy number
transcription factor
genome wide analysis