Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells.

Mahmoud M HabiballahSyam MohanNabeel Kashan SyedHafiz A Makeen Qazi Mohammad Sajid Jamal Hani AlothaidFarkad BantunAlaa AlhazmiAli HakamyYahia A KaabiGhalia SamlanMohtashim LohaniNeelaveni ThangavelMohamed Ahmed Al-Kasim

Published in: Drug design, development and therapy (2022)

These dual-loaded Chitosan nanoparticles demonstrated greater anti-proliferative activity against a breast cancer cell line (MCF-7) than doxorubicin-loaded Chitosan. This dual-loading strategy may enhance the anticancer potency of doxorubicin and reduce the clinical side effects associated with non-target tissue exposure.

Keyphrases

drug delivery
breast cancer cells
cancer therapy
growth hormone
endothelial cells
wound healing
oxidative stress
pluripotent stem cells
walled carbon nanotubes