Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells.
W Andrew ShockeyChristopher A KieslichCatera L WilderValencia WatsonManu O PlattPublished in: Cellular and molecular bioengineering (2019)
Together, this work has important implications for the development of mathematical model systems for protease inhibition in tissue destructive diseases, and consideration of preservation mechanisms by inhibitors that could alter perceived benefits of these treatment modalities.