Circ-ZNF236 mediates stem cells from apical papilla differentiation by regulating LGR4-induced autophagy.

Ya XiaoLuyao ChenYunlong XuRuiyang YuJiamin LuYue KeRong GuoTingjie GuHaowen YuYuxin FangZehan LiJinhua Yu

Published in: International endodontic journal (2024)

Circ-ZNF236 could activate autophagy through increasing LGR4 expression, thus positively regulating SCAPs odonto/osteogenic differentiation. Our findings suggested that circ-ZNF236 might represent a novel therapeutic target to prompt the odonto/osteogenic differentiation of SCAPs.

Keyphrases

cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
poor prognosis
mesenchymal stem cells
diabetic rats
bone marrow
high glucose
drug induced
long non coding rna