NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2.
Ryan P CardenasAhmad ZyoudAlan McIntyreRamiro AlberioNigel P MonganCinzia AllegrucciPublished in: Stem cell research & therapy (2024)
This study provides new molecular insights into the role of NANOG as a key determinant of pluripotency in TGCTs through the regulation of MIR9-2-5p, a novel epigenetic modulator of cancer stemness. Our data also highlight the potential negative feedback mediated by MIR9-2-5p on NANOG expression, which could be exploited as a therapeutic strategy for the treatment of TGCTs.
Keyphrases
- germ cell
- cancer stem cells
- stem cells
- embryonic stem cells
- epithelial mesenchymal transition
- poor prognosis
- long non coding rna
- cell proliferation
- papillary thyroid
- dna methylation
- gene expression
- long noncoding rna
- squamous cell
- squamous cell carcinoma
- risk assessment
- combination therapy
- signaling pathway
- climate change
- human health
- lymph node metastasis
- childhood cancer
- deep learning