VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn Neurons Mediates Neuropathic Pain in Rats.

Tzer-Bin LinCheng-Yuan LaiMing-Chun HsiehHsueh-Hsiao WangJen-Kun ChengYat-Pang ChauGin-Den Chen Hsien-Yu Peng

Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)

VPS26A-SNX27-dependent mGluR5 recycling plays a role in the development of neuropathic pain. The regulation of the VPS26A-SNX27 interaction that modifies mGluR5 trafficking and expression in the dorsal horn provides a novel therapeutic strategy for pain relief.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
poor prognosis
chronic pain