The Use of Cannabis and Cannabinoids in Treating Symptoms of Multiple Sclerosis: a Systematic Review of Reviews.

Suzanne NielsenRada GermanosMegan WeierJohn PollardLouisa DegenhardtWayne HallNicholas BuckleyMichael Farrell

Published in: Current neurology and neuroscience reports (2018)

We identified 11 eligible systematic reviews providing data from 32 studies, including 10 moderate to high quality RCTs. Five reviews concluded that there was sufficient evidence that cannabinoids may be effective for symptoms of pain and/or spasticity in MS. Few reviews reported conclusions for other symptoms. Recent high quality reviews find cannabinoids may have modest effects in MS for pain or spasticity. Future research should include studies with non-cannabinoid comparators; this is an important gap in the evidence.

Keyphrases

multiple sclerosis
meta analyses
chronic pain
spinal cord injury
mass spectrometry
neuropathic pain
pain management
ms ms
systematic review
botulinum toxin
sleep quality
upper limb
case control
randomized controlled trial
children with cerebral palsy
machine learning