Super-enhancer-associated gene CAPG promotes AML progression.
Qian MaMinyi ZhaoBing LongHai-Xia LiPublished in: Communications biology (2023)
Acute myeloid leukemia is the most common acute leukemia in adults, the barrier of refractory and drug resistance has yet to be conquered in the clinical. Abnormal gene expression and epigenetic changes play an important role in pathogenesis and treatment. A super-enhancer is an epigenetic modifier that promotes pro-tumor genes and drug resistance by activating oncogene transcription. Multi-omics integrative analysis identifies the super-enhancer-associated gene CAPG and its high expression level was correlated with poor prognosis in AML. CAPG is a cytoskeleton protein but has an unclear function in AML. Here we show the molecular function of CAPG in regulating NF-κB signaling pathway by proteomic and epigenomic analysis. Knockdown of Capg in the AML murine model resulted in exhausted AML cells and prolonged survival of AML mice. In conclusion, SEs-associated gene CAPG can contributes to AML progression through NF-κB.
Keyphrases
- acute myeloid leukemia
- poor prognosis
- signaling pathway
- gene expression
- allogeneic hematopoietic stem cell transplantation
- genome wide
- dna methylation
- binding protein
- transcription factor
- pi k akt
- induced apoptosis
- long non coding rna
- genome wide identification
- copy number
- oxidative stress
- small molecule
- inflammatory response
- cell cycle arrest
- metabolic syndrome
- immune response
- type diabetes
- cell proliferation
- insulin resistance
- skeletal muscle
- acute lymphoblastic leukemia
- combination therapy
- protein protein
- genome wide analysis