Impact of tocilizumab on anti-CD19 chimeric antigen receptor T-cell therapy in B-cell acute lymphoblastic leukemia.

Xiangmin WangBingpei ZhangQing ZhangHongyuan ZhouQian SunYi ZhouTianci LiDian ZhouZiyuan ShenJiaoli ZhangPing LiAibin LiangKeshu ZhouLu HanYongxian HuYun YangJiang CaoZhenyu LiKailin XuWei Sang

Published in: Cancer (2024)

Tocilizumab does not affect the efficacy of CAR T cells but may increase the likelihood of ICANS.

Keyphrases

acute lymphoblastic leukemia
rheumatoid arthritis
induced apoptosis
juvenile idiopathic arthritis
rheumatoid arthritis patients
cell cycle arrest
allogeneic hematopoietic stem cell transplantation
endoplasmic reticulum stress
disease activity
bone marrow
replacement therapy