Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.

Cristina RussoYvelise FerroSamantha MaurottiMaria Antonietta SalvatiElisa MazzaRoberta PujiaRosa TerraccianoGiuseppina MaggisanoRosario MareSandro GianniniStefano RomeoArturo PujiaTiziana Montalcini

Published in: Journal of translational medicine (2020)

Lycopene activates the WNT/β-catenin and ERK1/2 pathways, upregulates RUNX2, alkaline phosphatase, COL1A and downregulates RANKL Saos-2. These processes contributed to prevent bone loss in postmenopausal women.

Keyphrases

bone loss
postmenopausal women
cell proliferation
bone mineral density
signaling pathway
pi k akt
epithelial mesenchymal transition
transcription factor
stem cells
study protocol
clinical trial
double blind
randomized controlled trial
body composition
inflammatory response
toll like receptor
soft tissue