Activation of cholinergic anti-inflammatory pathway involved in therapeutic actions of α-mangostin on lipopolysaccharide-induced acute lung injury in rats.
Zhe YangQin YinOpeyemi Joshua OlatunjiYan LiShu PanDan-Dan WangJian ZuoPublished in: International journal of immunopathology and pharmacology (2021)
MAN activated CAP by increasing peripheral Ach and up-regulating α7nAchR expression, which eventually led to NF-κB inhibition and remission of acute inflammations.
Keyphrases
- lps induced
- anti inflammatory
- liver failure
- poor prognosis
- inflammatory response
- signaling pathway
- respiratory failure
- toll like receptor
- disease activity
- pi k akt
- oxidative stress
- nuclear factor
- ulcerative colitis
- binding protein
- chemotherapy induced
- hepatitis b virus
- systemic lupus erythematosus
- intensive care unit