Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression.

Gwenola Bougras-CartronArulraj NadaradjaneMarie-Pierre JoallandLisenn Lalier-BretaudeauJudith RaimbourgPierre-François Cartron

Published in: Cancers (2023)

Our data provide a biomarker (m6A-miR-125a-5p level) and two therapeutic solutions (anti-IGSF11 antibody and METTL3 inhibitor) that could potentially address the anti-PD1 therapy failure in the context of precision and personalized medicine.

Keyphrases

poor prognosis
dna methylation
electronic health record
genome wide
stem cells
gene expression
machine learning
mesenchymal stem cells
binding protein
bone marrow
smoking cessation