Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response.

Martina EspositoFrancesca MinnaiMassimiliano CopettiGiuseppe MiscioRita PernaAda PiepoliGabriella De VincentisMario BenvenutoPaola D'AddettaSusanna CrociMargherita BaldassarriMirella BruttiniChiara FalleriniRaffaella BrugnoniPaola CavalcanteFulvio Baggi Elena Maria Grazia CorsiniEmilio CiusaniFrancesca AndreettaTommaso A DraganiMaddalena FratelliMassimo CarellaRenato E MantegazzaAlessandra Renieri Francesca Colombo

Published in: Communications medicine (2024)

These results support the hypothesis that HLA genes modulate the response to Pfizer-BioNTech vaccine and highlight the need for genetic studies in diverse populations and for functional studies aimed to elucidate the relationship between HLA-A*03:01 and CD8+ cell response upon Pfizer-BioNTech vaccination.

Keyphrases

genome wide
endothelial cells
copy number
case control
single cell
cell therapy
stem cells
gene expression
induced pluripotent stem cells
bone marrow
binding protein
peripheral blood
mesenchymal stem cells
pluripotent stem cells