The alterations of glutamate transporter 1 and glutamine synthetase in the rat brain of a learned helplessness model of depression.

Kouhei YoshinoYasunori OdaMakoto KimuraHiroshi KimuraMasahito NangakuYukihiko ShirayamaMasaomi Iyo

Published in: Psychopharmacology (2020)

These results suggest that the LH rats experienced up-regulations of GLT-1 and GS in the CA-1, CA-3, DG, mPF, and NAc and a down-regulation of GS in the amygdala. It is possible that the effects of the GLT-1 and GS levels on astrocytes in the CA-1 and CA-3 are critical for the differentiation of resilience from vulnerability.

Keyphrases

protein kinase
climate change
transcription factor
social support
sleep quality
physical activity