Effects of genetic risk on incident type 2 diabetes and glycemia: the T2D-GENE lifestyle intervention trial.

Maria Anneli LankinenPetrus NuotioSusanna KauppinenNoora KoivuUlla TolonenKatriina Malkki-KeinänenAnniina OravilahtiTeemu KuulasmaaMatti UusitupaUrsula S Schwab Markku Laakso

Published in: The Journal of clinical endocrinology and metabolism (2024)

Our results showed that individuals with a high genetic risk for T2D benefited from a low-cost group-based intervention focusing on healthy diet and physical activity. Therefore, all individuals at risk of T2D should be encouraged to make lifestyle changes regardless of genetic risk.

Keyphrases

physical activity
type diabetes
genome wide
cardiovascular disease
randomized controlled trial
low cost
weight loss
copy number
metabolic syndrome
clinical trial
body mass index
insulin resistance
study protocol
depressive symptoms
skeletal muscle
phase iii
glycemic control
adipose tissue