Ketamine versus midazolam in bipolar depression with suicidal thoughts: A pilot midazolam-controlled randomized clinical trial.

Michael F GrunebaumSteven P EllisJohn G KeilpVivek K MoitraThomas B CooperJulia E MarverAinsley K BurkeMatthew S MilakM Elizabeth SubletteMaria A OquendoJ John Mann

Published in: Bipolar disorders (2017)

The study demonstrated feasibility. Suicidal thoughts were lower after ketamine than after midazolam at a trend level of significance, likely due to the small pilot sample. Memory improvement and BDNF are promising biomarkers. Replication is needed in an adequately powered full-scale trial.

Keyphrases

depressive symptoms
study protocol
pain management
clinical trial
randomized controlled trial
working memory
bipolar disorder
sleep quality
phase ii
physical activity
stress induced
open label