Prognostic impacts of the combined positive score and the tumor proportion score for programmed death ligand-1 expression by double immunohistochemical staining in patients with advanced gastric cancer.
Kohei YamashitaMasaaki IwatsukiKazuto HaradaKojiro EtoYukiharu HiyoshiTakatsugu IshimotoYohei NagaiShiro IwagamiYuji MiyamotoNaoya YoshidaYoshihiro KomoharaJaffer A AjaniHideo BabaPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2019)
CPS was shown to be a more useful assessment method of determining PD-L1 expression than TPS as a prognostic biomarker. This suggests that the total number of PD-L1-expressing cells, including tumor and immune cells, is a more sensitive prognostic biomarker than the number of PD-L1-expressing tumor cells in GC.