MRI Contrast-enhancement with superparamagnetic iron oxide nanoparticles amplify macrophage foam cell apoptosis in human and murine atherosclerosis.

Filip M E SegersAdele V RuderMarijke M WestraTwan LammersSeyed Mohammadali DadfarKarolin RoemhildTin Sing LamMarianne Eline Kooi Kitty B J M CleutjensFons K VerheyenGeert W H SchurinkGuido R M M Haenen Theo J C Van Berkel Ilze Bot Bente Halvorsen Judith C Sluimer Erik A L Biessen

Published in: Cardiovascular research (2022)

Ferumoxide and Ferumoxtran, but not Ferumoxytol, induced apoptosis of lipid-laden macrophages in human and murine atherosclerosis, potentially impacting disease progression in patients with advanced atherosclerosis.

Keyphrases

iron oxide nanoparticles
induced apoptosis
endothelial cells
cardiovascular disease
endoplasmic reticulum stress
induced pluripotent stem cells
oxidative stress
pluripotent stem cells
magnetic resonance imaging
contrast enhanced
cell proliferation
type diabetes