Dehalogenative Deuteration of Unactivated Alkyl Halides Using D2O as the Deuterium Source.
Aiyou XiaXin XieXiaoping HuWei XuYuanhong LiuPublished in: The Journal of organic chemistry (2019)
The general dehalogenation of alkyl halides with zinc using D2O or H2O as a deuterium or hydrogen donor has been developed. The method provides an efficient and economic protocol for deuterium-labeled derivatives with a wide substrate scope under mild reaction conditions. Mechanistic studies indicated that a radical process is involved for the formation of organozinc intermediates. The facile hydrolysis of the organozinc intermediates provides the driving force for this transformation.